Atorvastatin 80 mg kaufen is also effective (3).
In a large randomized clinical trial, combination of simvastatin (45 mg once daily) and pravastatin 40 mg once daily caused more reduction in total cholesterol (12.7%) than did simvastatin (5 mg once daily) and pravastatin 40 mg once daily (17.5% reduction); however, this association disappeared at two years follow up (15).
The reduction in total cholesterol has been more frequent with simvastatin than pravastatin; however, the difference appeared in first year (14).
In a recent pilot study of the cholesterol-lowering effects pravastatin, simvastatin, and a combination of both pravastatin and simvastatin, the risk of cardiovascular events did not differ between simvastatin and pravastatin combination users (16).
In another report, the cholesterol-lowering effect of three different doses simvastatin was compared with that of three different doses simvastatin and pravastatin, although not in a subgroup of women with hypercholesterolemia and at high risk of cardiovascular events, with an LDL-C level of at least 126 mg/dL to decrease 116 mg/dL, and with a C-reactive protein level of 1,200 mg/L to reduce 300 mg/L, (17). In this study, the lipid-lowering effect was greater with simvastatin than placebo.
Simvastatin or pravastatin combination of and simvastatin are also effective to lower triglyceride levels (4) and to reduce serum total or low-density lipoprotein cholesterol levels How much is lexapro generic (18). These effects are dose related health canada generic drug approval because the triglyceride levels decrease and lipoprotein cholesterol at the same time (23).
Dosing
There are no fixed dosing schedules for simvastatin or pravastatin. The usual dosing interval is 3 Buying clomid uk online to 6 months. When the patient is well controlled with the current dose regimen, it may be continued. In general, a gradual downward increase in dose is necessary to avoid hypoglycemic reactions; however, the dose should not be increased too quickly to cause hypoglycemia (24). The usual starting dose of simvastatin is 200 mg three times a day. One should monitor for hypoglycemia. However, if hypoglycemia develops within 24 hours or if there is a rapid or abrupt rise within the first 3 to 4 weeks of therapy, the dose should be increased gradually.
In addition to the usual dose, simvastatin may be started at higher doses when the dose of pravastatin is raised above the usual starting dose and is necessary to control hypotension or treat a serious cardiac condition such as congestive heart failure, acute myocardial infarction, or stroke (18). When simvastatin an appropriate dose of pravastatin or an appropriate dose of a mixture simvastatin and pravastatin is needed to manage a patient or control hypotension, the dose of simvastatin or pravastatin combination and should be reduced.
The dose should be increased gradually because an abrupt increase produces hypoglycemia. The dose should also be adjusted if the patient suffers angina during initial therapy.
The maximum tolerated dose of simvastatin is 240 mg three times a day, but this dose is increased in patients with underlying severe hypoglycemia when the patient's blood glucose level is below 110 mg/dL (24). Simvastatin should preferably be used with a.
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Atorvastatin is used to treat high cholesterol. Atorvastatin is also used to lower the risk of stroke, heart attack, or other heart complications in people with coronary heart disease or type 2 diabetes. Atorvastatin is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body. Atorvastatin reduces low-density lipoprotein (LDL) cholesterol and total cholesterol in the blood. Lowering your cholesterol can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease.
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